109 RA patients and 43 healthy controls were included in the study (Table 1). RA disease activity was evaluated by clinical examination through the disease activity score 28-CRP (DAS28-CRP), DAS28-CRP median was 2.6. A DAS28-CRP value greater than 5.1 indicates high disease activity, >3.2 to ≤5.1 means moderate, 2.6 to ≤3.2 means low disease activity and 0 to <2.6 indicates remission (17). This evidence concerns the gene CRP and rheumatoid arthritis.