We evaluated the crosstalk between RIG-I and DNA-PKcs during ZIKV infection analyzing the IFN-I/III-inducing transcription factors including IRF1, IRF3, IRF5, IRF7, and p65 (NF-κB subunit) (24, 25, 27, 29–31, 35). Here, IRF5 is linked to Zika virus infectious disease.