Elevated plasma ACE2 levels have been associated with increased levels of the pro-inflammatory interleukin-6 levels in severe COVID-19 disease (24), while the anti-inflammatory interleukin-13 IL-13 modulates ACE2 expression in airway epithelial cells in asthma and atopy (43); altogether these results support a link between ACE2 and inflammation. This evidence concerns the gene IL6 and asthma.