REN and acute respiratory distress syndrome: Anyhow, further studies addressing ACE2 levels of the different species and their enzymatic activity levels during SARS-CoV-2 infection and treatment are of interest for the potential metabolic impact in affected individuals, since imbalances in the renin-angiotensin system have been implicated in modulation of inflammation (37) and in several pathological conditions such as acute respiratory distress syndrome (38).