Through WGCNA and Lasso regression analysis, we finally screened three hub genes closely related to MYCN: ZNF695, CHEK1 and C15ORF42. Since MYCN is closely related to NB tumor immunity, the roles of these three genes in the regulation of the microenvironment of MYCN positive NB are worthy of further study. The gene discussed is TICRR; the disease is neuroblastoma.