At present, there are no studies on the effects of C15ORF42 in the microenvironment of children with NB, and no researches on the correlation between MYCN and C15ORF42. We found that there are specific binding sites of N-myc and N-myc was highly enriched in the transcription initiation region of CHK1 and C15ORF42 through UCSC database (http://genome.ucsc.edu/) and chip-seq data from Zeid R’s research (61)(Figures 10A, B), which suggests that N-myc may be an important transcription factor of CHK1 and C15ORF42. The gene discussed is TICRR; the disease is neuroblastoma.