In the training group, the AUC values of ZNF695, CHEK1 and C15ORF42 reached 0.956, 0.926 and 0.930 respectively (Figure 6C). In order to verify the results of the training group, we further calculated the AUC values of ZNF695 (0.954), CHEK1 (0.922) and C15ORF42 (0.921) in the validation group (Figure 6D). These results indicated that ZNF695, CHEK1 and C15ORF42 are closely related to MYCN positive NB, which is worthy of further study. The gene discussed is TICRR; the disease is neuroblastoma.