T25 exhibited increased expression of PD-1, CTLA4 and low expression of CCR7, CD45RA, CD127 and CD28 (Figure 4I), consistent with previous studies that a subset of tumor-reactive CD8+ TILs were positive for CD103 and CD39 and exhibited an exhausted tissue-resident memory phenotype (44, 45). The gene discussed is CTLA4; the disease is neoplasm.