Compared to symptomatic subjects, individuals who remained asymptomatic during their initial infection exhibited reduced anti-RBD IgG levels (7.4 [5.9-9.0] vs. 4.8 [1.9-5.9], P<.0001), neutralizing antibody titers (361.5 [202.0-640.0] vs. 113.0 [10.0-453.0], P=.007) and IFN-γ secreting cells (255.0 [101.3-476.3] vs. 95.0 [40.0-240.0] SFU/106 PBMCs, P=.02) (Figure 2A). The gene discussed is IFNG; the disease is infection.