The immune signature involved 12 genes, CCL2, CCL3, CCL4, CCL5, CCL8, CXCL9, CXCL10, CXCL11, CXCL13, CL18, CCL19 and CCL21, of which expression levels reflected tumor microenvironment in GC (44). The gene discussed is CXCL10; the disease is neoplasm.