The immune signature involved 12 genes, CCL2, CCL3, CCL4, CCL5, CCL8, CXCL9, CXCL10, CXCL11, CXCL13, CL18, CCL19 and CCL21, of which expression levels reflected tumor microenvironment in GC (44). Here, CCL21 is linked to neoplasm.