The immune signature involved 12 genes, CCL2, CCL3, CCL4, CCL5, CCL8, CXCL9, CXCL10, CXCL11, CXCL13, CL18, CCL19 and CCL21, of which expression levels reflected tumor microenvironment in GC (44). This evidence concerns the gene CCL5 and neoplasm.