Previous studies have shown that the transcription factor c-Myc-interacting zinc finger protein-1 (Miz1) was upregulated in allergic asthma, which in turn prevented the pro-Th1 skewing through the recruitment of histone deacetylase 1 (HDAC1) and transcriptional repression of IL-12 (77). The gene discussed is HDAC1; the disease is allergic asthma.