T cell specific loss of HDAC1 leads to an increase in Th2 type allergic airway inflammation, such as enhanced secretion of Th2 type cytokines, eosinophil recruitment to the lung (10).For example, HDAC1 is highly expressed and the most abundant member of the class I HDACs in allergic rhinitis and severe asthma (3, 11, 12). Here, HDAC1 is linked to asthma.