For example, F4/80+ macrophages were identified in the red pulp of the spleen (28), liver macrophages (Kupffer cells) were seen in areas of hepatitis induced by SLE IgG (17), and large numbers of CD11b+ monocytes/macrophage and CD11c+ DCs were detected in sites of skin inflammation; however, CD3+ T cells and CD20+ B cells were absent (23, 52). Here, ITGAM is linked to systemic lupus erythematosus.