On correlational analysis, there was no relationship between baseline (unstimulated) expression of NLPR3-assocaited genes (NLRP3, ASC, CASP1) and NLPR3-dependent cytokine production for any of the four PBMC stimulation conditions, either in individuals with T2DM, HCs or the combined cohort (Table S2). The gene discussed is CASP1; the disease is type 2 diabetes mellitus.