Nrp1-deficient MG promoted a reduction in the levels of interleukin (IL)-1α, CC motif chemokine receptor 8 (CCR8), and hypoxia-inducible factor 1-α (HIF1-α) and therefore delayed the progress of angiogenesis while promoting cytotoxic T cell and MG infiltration and decreasing the proportion of BMDMs in the tumor tissue. The gene discussed is NRP1; the disease is neoplasm.