The presence of mature cDC1 in tumor may lead to more efficient antigen presentation and cross-presentation of tumor antigens and subsequent augment antigen-specific T cell immunity (45) as shown in relevant results of antigen-specific effector CD8+ T cell (CD44+CD62L-) expansion and polyfunctional cytokine secretion after restimulated splenocytes with the OVA257-264 (SIINFEKL) peptide. This evidence concerns the gene CD44 and neoplasm.