MMP9 and neoplasm: Furthermore, the decrease of M2-like macrophages favors lung metastasis inhibition due to a lack of tumor-angiogenesis factors such as vascular endothelial growth factor (VEGF), epidermal growth factor (EGF) and fibroblast growth factor (FGF), and matrix metalloproteases (MMP-2 and MMP-9) which promote tumor angiogenesis, and metastasis (44).