IL2RG and infection: Within the last decade there have been numerous SCID pig models created, including IL2RG knockout (11–15), RAG1 and or RAG2 knockout (16–19), as well as double gene knockouts of IL2RG, RAG, or ARTEMIS (20–22), resulting in a range of translational research models, including models of infection with human norovirus (20), human iPSC engraftment (17), tumor melanoma cell engraftment (11), and allogeneic hematopoietic lineage engraftment (15, 17).