HMGB1 can disrupt the blood brain barrier (BBB), activate microglia and induce neurotoxic effects as a late mediator of inflammation (13, 14), and it has been implicated in a variety of neurological diseases such as ischemic stroke, epilepsy, multiple sclerosis, Alzheimer’s disease, and Parkinson’s disease, etc. (13, 15, 16). Here, HMGB1 is linked to nervous system disorder.