Although the first generation TKI of ERBB1/EGFR have not shown meaningful clinical activity in cancer patients with wildtype ERBB1/EGFR or mutant ERBB1/EGFR with T790M, new-generation TKI such as Afatinib are active even against wildtype or T790M mutant ERBB1/EGFR [56]. This evidence concerns the gene EGFR and cancer.