Given inflammation and placental hypoxia play crucial role in pathophysiology of preeclampsia (Roberts and Gammill, 2005), we examined the effect of pro-inflammatory cytokines (IL-6 and TNFα) and hypoxia on LGALS3 and LGALS3BP mRNA expression in placental cytotrophoblast and syncytiotrophoblast cells. The gene discussed is LGALS3; the disease is preeclampsia.