RYR1 and heart disorder: The RyR N-terminus has previously been implicated in neuromuscular and cardiac disease because of disrupted interaction with the central domain (Ikemoto and Yamamoto, 2002), also known as “helical domain-1” (Peng et al., 2016; Yan et al., 2015) and “bridging solenoid (BSol)” (des Georges et al., 2016).