Abnormal SR Ca2+ release due to missense mutations in RYR1 and RYR2 results in neuromuscular (e.g., malignant hyperthermia, MH) and cardiac disease (e.g., catecholaminergic polymorphic ventricular tachycardia, CPVT), respectively (Hernandez-Ochoa et al., 2016; Fowler and Zissimopoulos, 2022). The gene discussed is RYR2; the disease is heart disorder.