ANXA1 and experimental autoimmune encephalomyelitis: In contrast, in mouse models of allergic airway inflammation and experimental autoimmune encephalomyelitis AnxA1-deficient mice showed decreased Th1/Th17 polarization of T cells and reduced disease activity, suggesting proinflammatory effects of AnxA1 (D'Acquisto et al., 2007; Paschalidis et al., 2009).