Studies addressing the role of AnxA1 in models of Th17-dependent autoimmune diseases have produced conflicting results with protective effects reported in mouse models of retinal inflammation (Yazid et al., 2015), collagen-induced arthritis, contact dermatitis (Yang et al., 2013) and in patients with multiple sclerosis (Colamatteo et al., 2019). Here, ANXA1 is linked to multiple sclerosis.