However, in the context of hypertension, endothelial tissue may present with functional impairments, such as reduced bioavailability of nitric oxide (NO) and increased ET-1 concentrations, compromising the endothelium’s ability to respond to hemodynamic stimuli (Green et al., 2011; Konukoglu and Uzun, 2017). The gene discussed is EDN1; the disease is hypertensive disorder.