Some articles present the dephosphorylation function of CTDSP1: CTDSP1 regulates the phosphorylation state of Repressor Element 1 Silencing Transcription factor (REST) by preventing the target to the proteasome (40); CTDSP1 interacts with c-Myc both in vivo and in vitro that dephosphorylates c-Myc Ser62 and negatively regulates cancer cell proliferation (41); CTDSP1 interacts with the N terminus of Twist1, decreases Twist1 Ser68 and total Twist1 proteins, and inhibits the epithelial-to-mesenchymal transition (EMT), the migration and invasion in breast cancer cells (42). The gene discussed is TWIST1; the disease is cancer.