The expression of BMP4 is up-regulated in myocardial hypertrophy induced by pressure load and Ang II, the expression of BMP4 can induce cardiomyocyte hypertrophy, apoptosis, and myocardial fibrosis, and enhance the effect of myocardial hypertrophy induced by Ang II (13). The gene discussed is BMP4; the disease is Myocardial fibrosis.