PTEN and disease of peritoneum: Comparing mouse, spleen, and tumor masses (Supplementary Fig. S4), we observed STOSE and MOE-PTEN/KRAS cells tended to generate larger orthotopic tumors (Supplementary Fig. S4C), while ID8-derived models generated more extensive peritoneal disease (Supplementary Fig. S4D) and ID8-WT mice had higher ascites accumulation (Supplementary Fig. S4E).