Genes encoding homeobox TF family (HDG11, LOC18050300), C2C2(Zn) DOF zinc finger family (CDF2, LOC18038335), MADS box TF family (AGL22, LOC18036998), MYB-related TFs (MYB1R1, LOC18040130; RVE1, LOC18039807; HHO2, LOC18035441), Kelch repeat-containing protein (Krhp, LOC18052245), and phosphatidylinositol N-acetylglucosaminyl transferase (GPI1, LOC18036233) were downregulated throughout development in the HPP group. The gene discussed is PIGQ; the disease is hypophosphatasia.