Two DEGs associated with the TCA cycle, BMY3 (LOC18032416) and DPE2 (LOC18039894), were downregulated throughout development and ripening in the HPP group, whereas the 1,4-alpha-glucan-branching enzyme gene SBE2.2 (LOC18041588) and pullulanase gene ATPU1 (LOC18043634) were downregulated in the HPP group at 45 DAF and upregulated in the HPP group at 90, 135, and 180 DAF. The gene discussed is POLE2; the disease is hypophosphatasia.