The miRNA-encapsulated in exosomes control the target genes (nuclear factor kappa-B (NF-κB), signal transducer and activator of transcription (STAT) 1, and phosphatidylinositol 3 kinase/protein kinase B (PI3K/Akt), etc.)in the regulatory signaling pathway in immune response to treat the autoimmune diseases (Matsuzaka and Yashiro, 2022). The gene discussed is AKT1; the disease is autoimmune disease.