The increased expressions of Junctional Adhesion Molecule A (JAM-A), TNF-R2, and Chitinase 1 lead to increase platelet activation, angiogenesis, motor neuron destruction and microglia activation in the EVs of ALS patients (Czubak-Prowizor et al., 2022; Sjoqvist and Otake, 2022). Here, F11R is linked to amyotrophic lateral sclerosis.