LGR5 and hearing loss disorder: LGR5 regulates cochlear development by enhancing the Wnt/β-catenin signaling pathway (Cheng et al., 2017; McLean et al., 2017), especially LGR5-positive SCs have the potential to transdifferentiate into HCs, suggesting that it may be acted as a therapeutic target for hearing loss (Cox et al., 2014; Zhang S. et al., 2017; Smith-Cortinez et al., 2021; Ma et al., 2022).