Several VLGR1 mutations have been reported to cause Usher syndrome type IIC (USH2C) in humans, a genetically heterogeneous autosomal recessive disorder characterized by hearing impairment and epileptic seizures (Kimberling et al., 1995; Ebermann et al., 2007; Bonnet and El-Amraoui, 2012). This evidence concerns the gene ADGRV1 and hearing loss disorder.