There is mounting evidence that PP2A-mediated dephosphorylation of GABAB2(S783) and the associated reduction of cell surface GABAB receptors plays, beside in cerebral ischemia, an important role in neurological diseases such as addiction (Maeda et al., 2006; Padgett et al., 2012; Hearing et al., 2013) and depression (Lecca et al., 2016). Here, PTPA is linked to major depressive disorder.