MAPT and Alzheimer disease: Interestingly, despite effectively recapitulating the classical hallmarks of AD pathology, tau hyperphosphorylation and NFT formation were only observed in the spinal cord and not in the brain of the larval zebrafish (Tomasiewicz et al., 2002; Paquet et al., 2009; Fett et al., 2010; Lopez et al., 2017).