MAPT and Cognitive impairment: Its overexpression in zebrafish is associated with increased Aβ production, tau hyperphosphorylation, neuronal cell death, reactive gliosis, and cognitive impairments (Hooper et al., 2008; Llorens-Marítin et al., 2014; Jaworski et al., 2019; Toral-Rios et al., 2020).