Since then, cerebroventricular microinjections of synthetic Aβ peptides have been adopted as the most direct approach to model AD pathology in the zebrafish to mirror Aβ aggregation, tau protein phosphorylation, and induced toxicity (Nery et al., 2014; Bhattarai et al., 2016, 2017; Table 4). Here, MAPT is linked to Alzheimer disease.