TARDBP and amyotrophic lateral sclerosis: Testing the effects of three separate TARDBP mutations (A315T, A382T, and G348C) found in ALS patients, Kabashi et al. (2010) showed for the first time that mutant TDP-43 expression in the zebrafish led to abnormal motor axon development, motor neuron defects and toxicity, as well as severe deficits of motor function.