The genes most commonly associated with ALS show high conservation in zebrafish with sequence identity of over 70% for SOD1 (Da Costa et al., 2014), TARDBP (Kabashi et al., 2011), C9orf72 (Iyer et al., 2018), and FUS (Morrice et al., 2020). The gene discussed is TARDBP; the disease is amyotrophic lateral sclerosis.