FMR1 and autism: Human genetic studies on ASD have also yielded various ASD-risk gene sets, including SFARI genes (Abrahams et al., 2013),6 FMRP targets (Darnell et al., 2011; Werling et al., 2016), DeNovoMissense (protein-disrupting or missense rare de novo variants) (Iossifov et al., 2014; Werling et al., 2016), DeNovoVariants (protein-disrupting rare de novo variants) (Iossifov et al., 2014; Werling et al., 2016), and AutismKB (Autism KnowledgeBase) (Xu et al., 2012; Yang et al., 2018; Supplementary Table 4).