Increased concentrations of intrathecally produced Igs and substantial infiltration of ASC and B memory cells are observed in the spinal cord and the meninges of persistently infected mice, suggesting a potentially critical role for Igs and B cells in the chronic progressive phase of the demyelinating disease (Pachner et al., 2007a,b; DiSano et al., 2019a,b; Jin et al., 2020). The gene discussed is CUBN; the disease is demyelinating disease.