Numerous studies on the functions of Shank2 and Shank3, including those using mouse genetic approaches, have provided substantial insights into the mechanisms underlying Shank2- or Shank3-related brain disorders (Bozdagi et al., 2010; Peca et al., 2011; Schmeisser et al., 2012; Won et al., 2012; reviewed in Sheng and Kim, 2000, 2011; Boeckers et al., 2002; Bourgeron, 2009; Grabrucker et al., 2011; Sala et al., 2015; Schmeisser, 2015; Monteiro and Feng, 2017; Mossa et al., 2017, 2018; De Rubeis et al., 2018; Eltokhi et al., 2018; Ey et al., 2020; Jung and Park, 2022). The gene discussed is SHANK2; the disease is brain disorder.