Among the three known Shank family proteins, Shank2 and Shank3 have been associated with various brain disorders, including autism spectrum disorder (ASD), Phelan-McDermid syndrome, intellectual disability, and schizophrenia (Durand et al., 2007; Moessner et al., 2007; Gauthier et al., 2009; Berkel et al., 2010; Leblond et al., 2014; Phelan et al., 2022). The gene discussed is SHANK3; the disease is Phelan-McDermid syndrome.