CTSG and Paralysis: In addition, Cg phagocytosed by DCs forms a persistent actin cage at the periphery of the phagosome, a cage-like structure that spatially and functionally effectively prevents the fusion of phagosomes with lysosomes as well as inhibiting the formation of phagolysosomes and the further immune activation of DCs, leading to the immune paralysis of Cg by DCs.