IFNG and cryptococcosis: During cryptococcal infection, protective and nonprotective cytokines are produced by the host.The main protective cytokines include IFN-γ, IL-12, and IL-2, all of which enhance the macrophage expression of ROS in addition to RNS phenotypes and reduce the target organ fungal load, while decreasing host susceptibility (Wang et al., 2015; Firacative et al., 2018).