CD8A and neoplasm: Recently, based on Blast search for homology between TAA and Ags produced by gut microbiota (belonging to Firmicutes and Bacteroides phyla) combined with epitope prediction analysis considering HLA polymorphism, it was proposed that antigenic mimicry between TAA and microbial Ags produced by gut microbiota can be much broader and highly possible to influence anti-tumor immunity and tumor progression through the activation of TAA-specific CD8+ T cells by cross-reactive microbial Ags (Ragone et al., 2022).