The chromosome change rate and p53 mutation inactivation rate of HBV-related cancers are high (Song et al., 2021), leading to the activation of the mTOR signaling pathway (Luo et al., 2021) or WNT/β-catenin pathway (Dang et al., 2019), thus increasing the proliferation of cancer cells. The gene discussed is MTOR; the disease is cancer.