Previous report found, anti-HMGB1 mAb effectively reduced brain ischemia by efficient clearance of HMGB1 and inhibiting edema, ameliorates spontaneous arthritis model, prevent joint destruction, and repair cardiac pathological changes in experimental autoimmune myocarditis by suppress Th-17 cell [75, 79, 80]. Here, HMGB1 is linked to arthritic joint disease.