NTNG1 and neoplasm: In addition, we speculate that these tumor-supportive properties observed in CAF-sEVs could be partially attributed to the NetG1-dependent metabolite cargo provided to PDAC cells, of which Gln, a key amino acid used for survival in PDAC (10) that was shown to be dependent on NetG1 expression in CAF/ECM units (27), is significantly enriched compared with sEVs from NetG1KD CAFs.