Thus, plasma Lp(a) levels are elevated in patients with low eGFR and chronic kidney disease with large apo(a) isoforms.28) PAD patients frequently have low eGFR, which is a significant risk factor for CHD, CVD, and LE.10,11) High plasma Lp(a) levels were also a significant predictor for all outcomes in the current study. The gene discussed is LPA; the disease is chronic kidney disease.