Acupuncture at ST36 point is a promising, supplementary method for controlling sepsis inflammation, thus reducing the damage to the heart, lung, kidney, liver, gastrointestinal tract, and immune system [33] probably by reducing oxidative stress and inflammation [34], improving microcirculation disorders, maintaining dopamine-mediated immune balance [33], and inhibiting toll‐like receptor 4 (TLR4)/NF‐κB pathway [8] to reduce the release of inflammatory factors effectively. This evidence concerns the gene TLR4 and Sepsis.