According to the Transcriptome Data Analysis, we found that KXS, mainly by regulating the immune system (Osteoclast differentiation, complement cascades, TNF, etc.)and transduction pathways (NOD-like receptor, Antigen processing, etc.)reduced CORT-induced depression in mice; and there were 10 KDA genes (Cnp, Pllp, etc.), especially Pllp (mainly related to the immune mechanism of apical endocytosis controls [28]), with the strongest correlation in regulating depression of mice. The gene discussed is CNP; the disease is depressive disorder.