It is important to remind here that the minipigs used for this princeps study had a normal body weight, hormone variations were observed during anesthesia after short-term acute EA only, and the insulin response of normal-weight minipigs was shown to be different from that of obese subjects with basal hyperinsulinemia, higher insulin excursions, and insulin resistance [48,49]. This evidence concerns the gene INS and Hyperinsulinemia.