TNF-ɑ signaling also has been associated with a growth of salt appetite and sodium reabsorption stimulation in renal tubules by a mechanism that involve the suppressing of NOS, becoming a critical factor to induce hypertension (Ramseyer and Garvin, 2013; Zhang et al., 2014; Rudemiller and Crowley, 2016). This evidence concerns the gene NOS1 and hypertensive disorder.