Recently, a growing body of documents reported that β-Catenin is a target of MEG3 and is involved in a variety of human diseases downstream of MEG3, including Wilms’ tumor, glioma, and oral squamous cell carcinoma (Gong and Huang, 2017; Liu et al., 2017; Teng et al., 2020). Here, MEG3 is linked to oral cavity squamous cell carcinoma.