LncRNA actin alpha 2, smooth muscle antisense RNA 1 (ACTA2-AS1) can suppress malignant phenotypes of GC cells as it can function as a ceRNA to bind to miR-378a-3p and antagonize the inhibitory impacts of miR-378a-3p on the expression of phosphatidylinositol-specific phospholipase C X domain containing 2 (PLCXD2) (Liu et al., 2022). This evidence concerns the gene ACTA2 and gastric cancer.