Several studies indicated that GAS5 is associated with glucocorticoid resistance through its direct attachment to the GR protein by competing with glucocorticoid receptor element (GRE) and acting as a decoy GRE, preventing glucocorticoid-induced gene transcription upregulation, and decreasing GCs activity so contributing to the development of numerous autoimmune diseases (Wu et al., 2020) (Suo et al., 2018). This evidence concerns the gene GAS5 and autoimmune disease.