NR3C1 and autoimmune disease: Several studies indicated that GAS5 is associated with glucocorticoid resistance through its direct attachment to the GR protein by competing with glucocorticoid receptor element (GRE) and acting as a decoy GRE, preventing glucocorticoid-induced gene transcription upregulation, and decreasing GCs activity so contributing to the development of numerous autoimmune diseases (Wu et al., 2020) (Suo et al., 2018).