IL10 and autoimmune thrombocytopenic purpura: Corticosteroids, which are therapeutically variants of the glucocorticoids, are the principal therapy in ITP patients especially in chronic and resistant cases by different mechanisms include; raising the number of circulatory Tregs, reviving the Th1/Th2 proportion, restoring the Th17 count, constant with a rise in IL-10 and TGF- β, also, it alters B cell activation by lowering beta-cell stimulator (BlyS) and modulates dendritic cells (DCs) (Zufferey et al., 2017).