In ITP patients, plasma IFN-γ levels were shown to be higher, which hastens disease development by lowering CD4+CD25+FoxP3+ Treg levels (responsible for preserving self-tolerance by interaction with APC and lowering CD19+ B cell and CD8+ T cell responses) (Zufferey et al., 2017), (Talaat et al., 2014). Here, CD4 is linked to autoimmune thrombocytopenic purpura.