The most important clinically relevant findings were overexpressed lncRNAs IFNG-AS1 and GAS5 in the serum of childhood ITP patients [(median (IQR) = 3.08 (0.2–22.39), mean ± SD = 18.37 ± 19.54 for IFNG-AS1, and median (IQR) = 4.19 (0.9–16.91) for GAS5 than controls, Also, significant higher IFNG-AS1 and GAS5 were linked to patients with positive family history, patients with persistent or chronic ITP than those who are newly diagnosed, patients with no response or partial response to treatment when compared with patients who completely responded to treatment. Here, IFNG is linked to autoimmune thrombocytopenic purpura.