Studies increasingly show that changes in Orai1-mediated Ca2+ influx or aberrant Orai1 expression are associated with the progression of various cancers (Chalmers and Monteith 2018), although the exact role of Orai1 depends on the cancer type as well as the molecular or pathological subtypes (Perrouin Verbe et al., 2016; Xia et al., 2016). This evidence concerns the gene ORAI1 and cancer.