Additionally, snoRNAs have been proven to be closely related to the prognosis of patients with HCC and a potential molecular therapeutic target in HCC.16 Small nucleolar RNA H/ACA box 18 (SNORA18) transcribed from the chromosome 11q21 genomic region was identified as a regulator of tumor growth in pancreatic cancers.17,18 Currently, evidence assessing the particular effect of SNORA18 in the progression of HCC, and mediating the chemosensitivity of SFN, remains elusive. This evidence concerns the gene SNORA18 and familial pancreatic carcinoma.