As SFN contributes mainly to the blockade of PI3K/AKT, MEK/ERK and the EMT signaling pathways,25,26 we further confirmed that a combination of DDX24 knockdown and SFN administration exerted a synergistic effect on suppressing HCC growth through modulating the AKT/ERK pathway in vitro and in vivo. Here, AKT1 is linked to hepatocellular carcinoma.