SFN and hepatocellular carcinoma: This is ascribed to the complex interaction of multiple factors, including the activation or dysregulation of various signaling pathways, hypoxia-inducible responses, enrichment of the liver cancer stem cells (LCSC) and mitophagy of reactive oxygen species.6,7 Therefore, enhancing SFN sensitivity in HCC treatment is of great value for improving the OS of patients with HCC, and elucidating the molecular regulation underlying drug sensitivity is vital.