A KEGG pathway enrichment analysis revealed that DDX24 was likely involved in crucial biological signaling relating to promotion of HCC progression, including PI3K-Akt-mTOR, apoptosis, JAK-STAT, Notch and the Necroptosis signaling pathways (Figure 1e).22,23 In summary, a high expression of DDX24 is significantly related to patient overall survival, and DDX24 may be involved in the pathways regulating HCC development. This evidence concerns the gene MTOR and hepatocellular carcinoma.