Metastasis is a crucial determinant of cancer-related prognosis and OS time, and mounting evidence has suggested that the EMT signaling pathway plays a significant role in HCC metastasis and its sensitivity to SFN.7 As our results demonstrated that DDX24 could modulate the expression of EMT related proteins, we aimed to detect whether DDX24 combined with SFN treatment performed a synergistic inhibition on HCC cell migration. Here, DDX24 is linked to cancer.