For instance, SNORD76 enhanced the invasion of HCC cells through elevating the EMT pathway,16 while the snoU2_19 abrogation inhibited the HCC cell proliferation via Wnt/β-catenin signaling.30 Other reports have revealed that ACA11 knockdown represses the proliferation, migration and invasion of HCC cells,31 and SNORD52 highly expressed in HCC, could promote the development of HCC cells.32 However, the complicated relationship between snoRNAs and HCC is not clearly known, and there are few studies identifying the efficacy of snoRNAs on SFN sensitivity. Here, SCARNA22 is linked to hepatocellular carcinoma.