SNORA18 and neoplasm: Additionally, snoRNAs have been proven to be closely related to the prognosis of patients with HCC and a potential molecular therapeutic target in HCC.16 Small nucleolar RNA H/ACA box 18 (SNORA18) transcribed from the chromosome 11q21 genomic region was identified as a regulator of tumor growth in pancreatic cancers.17,18 Currently, evidence assessing the particular effect of SNORA18 in the progression of HCC, and mediating the chemosensitivity of SFN, remains elusive.