PKD-CNT (cluster5) and PKD-CDC1 (cluster0, Supplementary Fig. 13) differentially expressed MET, and PKD-CDC2 (cluster4) differentially expressed LCN2. MET and LCN2 were previously found to be essential for disease progression in an ADPKD mouse model30,31 (Fig. 7b). This evidence concerns the gene MET and autosomal dominant polycystic kidney disease.