CDKN1B and cyst: While CDKN1B and CDKN1C expression was higher in normal subtypes (Supplementary Fig. 15b), senescence-related CDK inhibitors CDKN1A and CDKN2A were more abundant in PKD-CDC subtypes (Supplementary Fig. 15a, b), suggesting that cyst-lining cells may be prone to cellular senescence due to cellular stress.