A majority of TNFα signaling was predicted to be from CNT_PC cluster in our ligand-receptor analysis (Fig. 4), and TNFα was primarily detected in the PKD-CDC2 subset (Fig. 7c), suggesting that PKD-CDC2 is a major source of TNFα signaling in ADPKD kidneys. The gene discussed is TNF; the disease is autosomal dominant polycystic kidney disease.