In agreement with the geneset enrichment analysis, we found the motifs of transcription factors related to NF-κB pathway (RELA), IL6-induced inflammation (STAT3) and TGFβ signaling (SMAD2::SMAD3::SMAD4) were enriched in many cell types of ADPKD kidneys. The gene discussed is SMAD2; the disease is autosomal dominant polycystic kidney disease.