MPPE1 and autosomal dominant polycystic kidney disease: PKD-CNT (cluster5) and PKD-CDC1 (cluster0, Supplementary Fig. 13) differentially expressed MET, and PKD-CDC2 (cluster4) differentially expressed LCN2. MET and LCN2 were previously found to be essential for disease progression in an ADPKD mouse model30,31 (Fig. 7b).