Multivariate analysis showed that the independent risk factors for OS were tumor size (>10 cm vs. ≤10 cm, HR=1.3; 95% CI, 1.1–1.7; p=0.019), tumor number (>3 vs. ≤3, HR=1.5; 95% CI, 1.1–1.9; p<0.001), PVTT (Vp3-4 vs. Vp1-2 and none, HR=1.6; 95% CI, 1.2–2.0; p<0.001), metastasis (presence vs. absence, HR=1.9; 95% CI, 1.5–2.5; p<0.001), AFP (>400 vs. ≤400, HR=1.4; 95% CI, 1.1–1.8; p=0.01), and ALBI (grade 2 vs. grade 1, HR=1.5; 95% CI, 1.2–1.9; p<0.001). The gene discussed is AFP; the disease is neoplasm.