The frequencies of grade 3–4 elevated alanine aminotransferase and elevated aspartate aminotransferase and the frequencies of any grade fatigue, fever, sensory neuropathy, alopecia, nausea, elevated aspartate aminotransferase, and prolonged PT were also significantly higher in the HAIC 2d group, while the frequency of any grade elevated creatine was also significantly higher in the HAIC 1d group. This evidence concerns the gene GPT and Sensory neuropathy.