Most recently, NAD(P)H has been uncovered to be engaged in the regeneration of CoQ10 that traps lipid peroxyl radicals, placing CoQ10–NAD(P)H pathway in a stand‐alone system in parallel with GPX4 to inhibit phospholipid peroxidation and ferroptosis.[32] Our study demonstrates that the early changes in metabolism during ischemia involve rewiring of KP, which acts as a key initiator of phospholipid peroxidation and liver damage during subsequent reperfusion. Here, GPX4 is linked to ischemia.