A lipidomics analysis report indicates that the arachidonate 12‐lipoxygenase (ALOX12) is markedly elevated in the hepatocytes during ischemia, promoting the accumulation of 12‐hydroxyeicosatetraenoic acid (12‐HETE) and inflammatory that aggravates liver injury.[5] So far, the changes in the global metabolite level during hepatic ischemia stage have not been explored. Here, ALOX12 is linked to ischemia.