The functions of CBX1 in promoting NPC tumorigenesis and immune evasion are further uncovered, in which CBX1 facilitates transcriptional repression of MAP7 via H3K9me3‐mediated heterochromatin formation and activates IFN‐γ‐STAT1 signaling‐mediated PD‐L1 upregulation. This evidence concerns the gene MAP7 and nasopharyngeal carcinoma.