In lung cancer, high expression of MAP7 was correlated with favorable overall survival.[39] In contrast, MAP7 was overexpressed and positively correlated with a poor prognosis in cervical cancer[40] and acute myeloid leukemia.[41] Here, we showed that knockdown of MAP7 in NPC promoted cell proliferation, migration and invasion and rescued the inhibition of malignant phenotypes in CBX1‐depleted cells. This evidence concerns the gene MAP7 and nasopharyngeal carcinoma.