Here, beginning with the hypothesized existence of an interaction between m6A and histone methylation regulators, we analyzed the m6A modification profile in paired NPC tissues and identified that CBX1 (also called HP1‐β), a histone methylation reader protein, was highly expressed with m6A hypomethylation in metastatic NPC. The gene discussed is TFF3; the disease is nasopharyngeal carcinoma.