In lung cancer, high expression of MAP7 was correlated with favorable overall survival.[39] In contrast, MAP7 was overexpressed and positively correlated with a poor prognosis in cervical cancer[40] and acute myeloid leukemia.[41] Here, we showed that knockdown of MAP7 in NPC promoted cell proliferation, migration and invasion and rescued the inhibition of malignant phenotypes in CBX1‐depleted cells. The gene discussed is CBX1; the disease is nasopharyngeal carcinoma.