To explore the mechanisms underlying the oncogenic role of CBX1 in NPC, we performed RNA‐seq in sgNC and sgCBX1‐1 SUNE1 cells and chromatin immunoprecipitation (ChIP) sequencing (ChIP‐seq) in SUNE1 cells with CBX1 overexpression to identify potential targets of CBX1. Here, CBX1 is linked to nasopharyngeal carcinoma.