CHUK and nasopharyngeal carcinoma: For example, the histone methyltransferase EZH2 represses IKKα expression via H3K27 histone methylation and impairs NPC differentiation.[7] Silencing of KDM4A, a histone demethylase, can inhibit NPC migration and invasion.[8] However, the mechanisms involving these histone methylation regulators in NPC progression are largely unknown.