To confirm the biological relevance of our data obtained in vitro, we used a cutaneous granuloma model, in which two biogel “plugs” were injected into the right (addition of lipopolysaccharide (LPS) plus S100A8/S100A9‐tetramer) and the left flank (addition of LPS only) of the mice. Here, S100A8 is linked to Granuloma.